人类对衰老机制的探索从未停止。2023年《Cell》期刊提出的“衰老十二大标志”框架,将基因组不稳定、端粒损耗、表观遗传改变等现象纳入衰老特征,但未能阐明其因果关系[2]。2025年发表于《Aging and Disease》的这项研究直击核心,提出端粒(Telomere)与核糖体DNA(rDNA)的协同缩短是驱动细胞程序化衰老的根本原因,而其他衰老标志均为这一过程的衍生结果。
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